Amniotic stem cell transplantation therapy for type 2 diabetes: 3 years' follow-up report
Abstract
OBJECTIVE: These case series present a retrospective analysis of clinical effects that an allogeneic amniotic cell transplantation can have in treating 4 patients with type 2 diabetes.
PATIENTS AND METHODS: Eligible diabetic patients were onset within 3 years, with fasting blood glucose > 7.0 mmol/l. Stem - cells that are collected from neonatal amniotic membrane when a child is born (2 x 107 cells) - are used for the treatment of these patients. Measured by the flow cytometry, stem cells transfer clusters of differentiation CD113 and CD34 at a high level, and through the femoral artery on the left, they are administered into the patient's pancreatic dorsal artery.
RESULTS: The major outcome of the study is the improvement of glycemic control. After withdrawing insulin completely, 13.2 months later, there is a reincrease in the level of blood glucose of the patient. After adjusting their treatment again, no one required using insulin again; only need metformin (250-500 mg/day) to control blood glucose levels.
CONCLUSIONS: Since this therapy showed no effects on C-peptide, our results suggested one plausible therapeutic strategy improving glycemic control by increasing insulin sensitivity.
How strong is the evidence?
Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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