Use of Testosterone-Lowering Medication in Patients With Intellectual Disabilities and Problematic Sexual Behaviour: A Case Series
Abstract
Background: Testosterone-lowering medication (TLM) is used in severe cases of paraphilic disorders and problematic sexual behaviour, but its use in patients with intellectual disability is not well characterised.
Method: A nationwide survey identified five male patients with intellectual disability who had received TLM in specialised outpatient clinics.
Results: Four patients showed reduced problematic sexual behaviour during treatment; three relapsed after discontinuation. Adverse effects included osteoporosis, hypertension, depression and suppressed sexual development. Monitoring and access varied regionally.
Conclusions: TLM may be effective in selected patients with intellectual disability but requires careful monitoring and ethical oversight.
How strong is the evidence?
Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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