Case Report: Food-based enteral formula in the nutritional management of children with hyperinsulinism: single center retrospective case series
Abstract
Context: Hyperinsulinism is characterized by dysregulated insulin secretion and is typically associated with reduced fasting tolerance. Long-term hyperinsulinism management includes nutrition and medication to normalize plasma glucose levels. Management of enteral feeds and oral intake is integral to the clinical management strategy in children with hyperinsulinism. A new generation of commercial Food Based Enteral Formulas (FBF) consists of rehydrated food, whole-food protein sources and a mixture of soluble and insoluble fiber.
Objective: Review the tolerance of a food-based enteral formula for the nutritional management of children with hyperinsulinism.
Methods: A single-center retrospective case series to explore the dietetic practice of prescribing a commercially available FBF (Compleat® pediatric, Nestlé Health Science) in children with congenital hyperinsulinism (CHI) or postprandial hypoglycemia (PPH). Data were collected on demographics, gastrointestinal symptoms, anthropometrics, percentage glucose management indicators (GMI%) and hypo/hyperglycemic episodes.
Results: Data were collected on eight children; six were diagnosed with CHI and two children had PPH. The mean age was 1.4 years (0.4SD). All children had a gastrostomy for enteral nutrition. Six of the eight children were prescribed proton pump inhibitors or stool softeners to manage gastroesophageal reflux and/or constipation symptoms. Within one month of children being prescribed FBF dietitians documented…
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Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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