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Management of a patient with severe insulin resistance

Arulanandam B, Garfield N

JCEM case reports, 2026

Abstract

We report the case of a 48-year-old man with type 2 diabetes with severe insulin resistance, requiring more than 1000 units of insulin per day. Our case highlights the challenges in treating patients with severe insulin resistance, including ruling out secondary causes and using less-commonly prescribed therapies such as U-500 insulin.

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