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Integrating Bioenergetic Therapy Model with Neuropsychopharmacological Interventions in Long-standing Treatment-resistant Schizophrenia: Case Series and Review of Literature

Khairkar P, Chadha D, Kamble A, Khivsara A, Modi R, Khairkar R

Annals of neurosciences, 2026

Abstract

Background: The bioenergetic therapy model combines holistic somatic therapy with psychotherapy, addressing both physical and emotional aspects of healing. In cases of long-standing treatment-resistant schizophrenia (TRS), which may persist for over two decades, finding effective therapeutic strategies remain a significant challenge. Despite numerous treatment options, no existing reports integrate somatosensory therapy with neuropsychopharmacological interventions for these complex cases.

Purpose: To demonstrate the integration of bioenergetic therapy with neuropsychopharmacological interventions in managing long-standing treatment-resistant schizophrenic cases.

Methods: Two cases of long-standing schizophrenia were illustrated for how we integrated somatosensory bioenergetics principles with neuropsychopharmacology. They had emotional and/or physical abuse in addition to psychotic symptoms without any pre-morbid schizoid/paranoid traits or psychiatric history of substance abuse, and presented to us with complaints of high sensitivity to rejection, persecutory delusions, third-person auditory hallucinations, irritability, episodic aggression, psychomotor retardation, disturbed sleep, and declining professional performance.

Results: A systematic cognitive deficit evaluation, slow building of clozapine (100 mg/day), integration of somatosensory therapy, family system therapy model and cognitive enhancement therapy were integrated. This integration of somatosensory therapy…

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