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A case and literature review of hypokalemic periodic paralysis associated with heavy cola consumption

Chen W, Pang Y, Qiu J

Frontiers in nutrition, 2026

Abstract

This clinical case report involves a 34-year-old male patient with a history of type 2 diabetes and schizophrenia, who took oral olanzapine for a long time and visited the hospital several times because of lower limb fatigue caused by hypokalemia. Although the symptoms were alleviated by potassium supplementation, they recurred. The patient was hospitalized because of hypoglycemia and fatigue. Laboratory examination revealed hypokalemia, After supplementing potassium, the symptoms gradually eased. To prevent the patient from experiencing hypokalemia again, we asked about his diet and found that he had an unbalanced diet with a lot of cola consumption. To confirm that heavy cola drinking and an unbalanced diet might be related to hypokalemic periodic paralysis, we advised the patient to stop drinking cola and maintain a balanced diet. Follow-up studies showed that after stopping cola and eating a balanced diet, the patient did not experience hypokalemia again. This suggests that drinking a lot of cola is related to episodes of hypokalemic periodic paralysis. Therefore, when doctors encounter patients with hypokalemic periodic paralysis in routine practice, they should pay attention to the patient's eating habits during consultations to avoid missing a diagnosis and recurrence.

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