A Novel Supplement Regimen for Healthy Aging: A Case Series
Abstract
Objective: This case series aims to evaluate a novel supplement regimen for healthy aging in older adults, assess its potential to reduce reliance on prescription drugs like metformin and statins, and inform the design of a larger clinical trial. Background: The convergence of an aging population and increasing prevalence of age-related chronic diseases continues to strain limited healthcare resources and exert financial pressures on healthcare systems and individuals alike. For this reason, cost-effective, readily available solutions are needed more than ever to help reduce the disease burden among older adults. Methods: Participants included 10 men and women, aged 62-91 years, who were given a supplement regimen providing niacin (extended-release tablets), dihydroberberine (sustained-release tablets), taxifolin (sustained-release tablets), and mixed tocotrienols (immediate-release softgels) along with diet instructions. Participants were required to share the study protocol with their personal doctors, and agree to periodic in-person home visits. Blood tests (blood lipid profile, comprehensive metabolic profile, uric acid, homocysteine, and HbA1c) were completed at baseline and repeated at 6 weeks, 12 weeks and quarterly thereafter to monitor benefits and possible adverse side effects, unless abnormal tests warranted closer monitoring. Participants underwent cognitive and well-being assessments at baseline and study completion. Results: Supplement intervention lasted 16…
How strong is the evidence?
Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health. Reported size: 10 participants or records.
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