Delafloxacin: what does a new fluoroquinolone offer?
Abstract
Delafloxacin is a novel anionic fluoroquinolone with a different chemical structure from currently marketed fluoroquinolones, which gives it distinct physicochemical characteristics, being active in both acidic and neutral environments. Delafloxacin is also unique in showing a dual-targeted equipotent inhibition of the essential bacterial enzymes DNA gyrase and topoisomerase IV, which may explain the very low frequencies of spontaneous mutations in vitro. It shows potent in vitro activity against a broad spectrum of Gram-negative bacteria, including some fluoroquinolone-resistant strains, and increased efficiency against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, although it is always necessary to determine the in vitro activity of delafloxacin against fluoroquinolone-resistant isolates. Delafloxacin exhibits linear pharmacokinetics, a wide volume of distribution, and a concentration-dependent pattern of antimicrobial killing, a property that allows the use of high doses for greater effectiveness in some difficult-to-treat infections. Delafloxacin is available for clinical use in oral and intravenous formulations and has been approved for the treatment of acute bacterial skin and skin-structure infections and community-acquired bacterial pneumonia based on the results from phase II and III clinical trials. Overall, delafloxacin has been well tolerated and has a low profile of drug-drug interactions. Its activity in local acidic…
Read the paper
Related studies
- Association of lower urinary tract symptoms and OAB severity with quality of life and mental health in China, Taiwan and South Korea: results from a cross-sectional, population-based study
- Ten-Day Quadruple Therapy Comprising Low-Dose Rabeprazole, Bismuth, Amoxicillin, and Tetracycline Is an Effective and Safe First-Line Treatment for Helicobacter pylori Infection in a Population with High Antibiotic Resistance: a Prospective, Multicenter, Randomized, Parallel-Controlled Clinical Trial in China
- The Role of the NLR and PLR in Urinary Tract Infection
- Threat of Antimicrobial Resistance among Pilgrims with Infectious Diseases during Hajj: Lessons Learnt from COVID-19 Pandemic
- Leclercia adecarboxylata urinary tract infection in a patient with bladder cancer and recurrent hematuria
- A Case Series of Staphylococcus lugdunensis Infection in Cancer Patients at an Academic Cancer Institute in the United States
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.