Polycystic ovarian syndrome and long-term risk of acute myocardial infarction and ischaemic stroke
Abstract
Aims: Polycystic ovary syndrome (PCOS) affects 5-20% of reproductive-aged women and is linked to cardiovascular risk factors and atherosclerosis. Yet, its long-term association with atherosclerotic cardiovascular disease remains uncertain and will be the focus of this study.
Methods and results: Women diagnosed with PCOS (1995-2024) were identified through Danish nationwide registries and matched 1:4 with female controls from the background population by age and year of index. The primary outcome was a composite of acute myocardial infarction and ischaemic stroke, with the individual components serving as secondary outcomes. The study included 25 513 women with PCOS and 102 052 matched controls (median age 29.9 years). Women with PCOS had a higher prevalence of cardiovascular risk factors compared with controls. The 25-year cumulative incidence of the composite outcome was higher in women with PCOS [3.4% (95% confidence interval (CI) 2.8-4.2%)] compared with controls [2.0% (95% CI 1.8-2.3%)]. In Cox regression analyses, PCOS was associated with an increased risk of the composite outcome [unadjusted hazard ratio (HR) 1.82 (95% CI 1.56-2.11), adjusted HR 1.53 (95% CI 1.30-1.81)], acute myocardial infarction [unadjusted HR 1.86 (95% CI 1.45-2.39), adjusted HR 1.58 (95% CI 1.21-2.07)], and ischaemic stroke [unadjusted HR 1.83 (95% CI 1.52-2.22), adjusted HR 1.56 (95% CI 1.27-1.91)]. The associations did not vary by use of oral contraception, metformin, anti-androgens,…
Read the paper
Related studies
- Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis
- Identification of key genes associated with polycystic ovary syndrome (PCOS) and ovarian cancer using an integrated bioinformatics analysis
- Identification of key pathways and genes in polycystic ovary syndrome via integrated bioinformatics analysis and prediction of small therapeutic molecules
- Regulation of Androgen Receptor Expression Alters AMPK Phosphorylation in the Endometrium: In Vivo and In Vitro Studies in Women with Polycystic Ovary Syndrome
- Effect of oral administration of low-dose follicle stimulating hormone on hyperandrogenized mice as a model of polycystic ovary syndrome
- Systems pharmacology to investigate the interaction of berberine and other drugs in treating polycystic ovary syndrome
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.