Hormonal Imbalance and Gut Dysbiosis: Emerging Perspectives in Women's Health
Abstract
The gut microbiota plays a crucial function in reproductive well-being and is vital for maintaining fundamental physiological balance. This article surveys the mutual relationships between the gut flora and the female reproductive system, which are maintained through metabolic, immunological, and neuroendocrine mechanisms, thereby creating the gastrointestinal-reproductive axis. Dysbiosis, which results from an imbalance in microbial levels, has been related with reproductive diseases, such as polycystic ovary syndrome (PCOS), infertility, endometriosis, and pregnancy-related problems. Modulation of the gut microbiota via targeted synthetic materials, such as metformin, dietary phytocompounds, synbiotics, probiotics, and prebiotics, affects hormonal levels, glucose resistance, and monthly cycle regulation, showcasing favorable prospects for medical care. This review elucidates the molecular and cellular processes underlying gut-reproductive relationships and assesses the potential of microbiome-targeted medications as viable clinical approaches for enhancing fertility outcomes. Further attention should be devoted to determining the crosstalk between endometrial disruption, hormonal imbalance, and inflammation.
Read the paper
Related studies
- Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis
- Identification of key genes associated with polycystic ovary syndrome (PCOS) and ovarian cancer using an integrated bioinformatics analysis
- Identification of key pathways and genes in polycystic ovary syndrome via integrated bioinformatics analysis and prediction of small therapeutic molecules
- Regulation of Androgen Receptor Expression Alters AMPK Phosphorylation in the Endometrium: In Vivo and In Vitro Studies in Women with Polycystic Ovary Syndrome
- Effect of oral administration of low-dose follicle stimulating hormone on hyperandrogenized mice as a model of polycystic ovary syndrome
- Systems pharmacology to investigate the interaction of berberine and other drugs in treating polycystic ovary syndrome
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.