An experimental study on the efficacy of Shatapushpa Churna in managing PCOS symptoms in a rat model: An Ayurvedic approach
Abstract
Background: Polycystic Ovary Syndrome (PCOS) is one of the most prevalent metabolic and reproductive disorders affecting women of reproductive age. It is characterized primarily by menstrual dysfunction and androgen excess, which impact quality of life. PCOS is also associated with various comorbidities, including metabolic syndrome, reproductive abnormalities, psychological stress, and an increased risk of chronic illnesses such as type II diabetes and cardiovascular disease.
Objectives: This study aimed to evaluate the therapeutic potential of Shatapushpa Churna in managing PCOS-like symptoms using a rat PCOS model. The primary focus was on assessing its effects on estrous cyclicity, glucose metabolism, body weight, hormonal profile, and ovarian histomorphology.
Methods: A PCOS-like condition was induced in adult female Wistar rats by administering letrozole (2 mg/kg body weight, orally) once daily for 21 days. Model validation was based on irregular estrous cycles, impaired glucose tolerance, increased body weight, and altered hormonal profiles. PCOS-positive rats were then treated for 45 days with Shatapushpa Churna at three graded doses: low (0.62 g/kg b.w.), mid (1.24 g/kg b.w.), and high (1.85 g/kg b.w.). A standard reference group received metformin (300 mg/kg b.w.). Therapeutic outcomes were assessed through estrous cycle monitoring, oral glucose tolerance test (OGTT), serum hormonal assays, and ovarian histopathological examination.
Results: Rats treated with…
Read the paper
Related studies
- Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis
- Identification of key genes associated with polycystic ovary syndrome (PCOS) and ovarian cancer using an integrated bioinformatics analysis
- Identification of key pathways and genes in polycystic ovary syndrome via integrated bioinformatics analysis and prediction of small therapeutic molecules
- Regulation of Androgen Receptor Expression Alters AMPK Phosphorylation in the Endometrium: In Vivo and In Vitro Studies in Women with Polycystic Ovary Syndrome
- Effect of oral administration of low-dose follicle stimulating hormone on hyperandrogenized mice as a model of polycystic ovary syndrome
- Systems pharmacology to investigate the interaction of berberine and other drugs in treating polycystic ovary syndrome
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.