The application of metformin in the pregnant patients with polycystic ovary syndrome
Abstract
Metformin has a role in menstrual cycle adjustment,ovulation promotion and weight control of patients with polycystic ovary syndrome (PCOS) by improving insulin resistance (IR),lowering androgen level and regulating lipid metabolism,which can increase the rate of pregnancy and is widely applied in clinical treatment.Because of IR aggravation,patients with PCOS are often confronted with adverse complications,such as early pregnancy loss,gestational diabetes mellitus (GDM),pregnancy induced hypertension and pree-clampsia.Metformin can reduce early pregnancy loss and delay the occurrence of GDM in patients with PCOS,and shows no significant effects on fetal outcome,the postnatal growth and development of fetus.
Key words:
Metformin; Polycystic ovary syndrome; Pregnancy
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