Impact of metformin on C-reactive protein levels in women with polycystic ovary syndrome: a meta-analysis
Abstract
// Yong Chen 1,* , Meng Li 2,* , Hongli Deng 3 , Sheying Wang 1 , Lihua Chen 1 , Ningsha Li 1 , Dan Xu 1 and Qiguang Wang 4 1 Department of Clinical Laboratory, The First Hospital of Changsha City, Hunan, People’s Republic of China 2 Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Guangxi, People’s Republic of China 3 Department of Clinical Laboratory, People’s Hospital of Liuyang City, Hunan, People’s Republic of China 4 Department of Clinical Laboratory, The First Affiliated Hospital of Hunan Normal University, People’s Hospital of Hunan, Hunan, People’s Republic of China * Thesse authors have contributed equally to the article Correspondence to: Qiguang Wang, email: // Keywords : metformin, CRP, polycystic ovary syndrome, meta-analysis Received : August 31, 2016 Accepted : January 27, 2017 Published : March 08, 2017 Abstract The impact of the recommended first-line treatment with metformin on C-reactive protein (CRP) levels in patients with polycystic ovary syndrome (PCOS) is still controversial. We conducted a meta-analysis of studies reporting the impact of metformin on serum CRP levels in women with PCOS. The weighted mean differences (WMDs) and the corresponding 95% confidence intervals (CIs) were used to assesse the effects. GRADE approach was used to assesse the quality of the evidence. A total of 20 studies that included 433 women with PCOS were analyzed. CRP levels significantly decreased after metformin treatment…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 433 participants or records.
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