Meta-Analysis of the Efficacy of Yasmin Combined with Metformin in the Treatment of Polycystic Ovary Syndrome
Abstract
Objective: To evaluate the efficacy and safety of Yasmin combined with metformin in the treat-ment of Polycystic ovary syndrome (PCOS). Methods: the databases of CNKI, Wanfang, VIP, CBM, PubMed, the Cochrane Library and EMBASE were searched from December 8, 2023. A total of 31 studies were included, with a total of 2792 subjects, including 1396 in the observation group and 1396 in the control group. Results: meta-analysis showed that compared with the control group, the clinical overall response rate (RR = 1.25, 95%CI [1.18, 1.33], P 0.05) and follicle-stimulating hormone FSH (MD = − 0.40, 95%CI [ − 0.92, 0.13], P > 0.05). Conclusion: Combined use of Yasmin and metformin can improve hormone disturbance levels, increase pregnancy capacity, and reduce high body fat in patients with PCOS.
How strong is the evidence?
Evidence Hub reads this as a meta-analysis. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 2,792 participants or records.
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