Fatal Metformin Poisoning: Adolescent Case Report
Abstract
Metformin is a biguanide oral hypoglycemic agent used for non-insulin dependent diabetes mellitus. Lactic acidosis still the most important and dangerous side effect of acute and chronic metformin use, its mortality can reach up 50%. Metformin poisoning in children remains rare and is very rarely reported in the literature. The curative treatment is based on early extrarenal purification by haemodialysis or haemodiafiltration. However, the prognosis of high doses of metformin can be fatal. We are reporting the case of a 14-year-old female patient who intentionally overdosed on metformin, resulting in lactic acidosis and death.
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Metformin as an adjuvant in breast cancer treatment
- Metformin Lysosomal Targeting: A Novel Aspect to Be Investigated for Metformin Repurposing in Neurodegenerative Diseases?
- Aberrant HSF1 signaling activation underlies metformin amelioration of myocardial infarction in mice
- Metformin induces ZFP36 by mTORC1 inhibition in cervical cancer-derived cell lines
- Protein Interaction Network for Identifying Vascular Response of Metformin (Oral Antidiabetic)
- Preventing Long COVID With Metformin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.