Efficacy of a Gut-microbiota Targeted Nutritional Intervention for Promoting Gut Barrier Integrity During Short-term Exposure to Hypobaric Hypoxia
Abstract
The aim of this randomized, crossover clinical trial is to determine the efficacy of a gut microbiota-targeted nutritional intervention containing a blend of fermentable fibers and polyphenols (FP) for mitigating increases in GI permeability, and decrements in immune function and neuropsychologic performance following rapid ascent to simulated high altitude. Fifteen healthy young adults will participate in each of three study phases that include a 14-day supplementation period in which participants will consume 1 of 2 supplement bars: placebo (PL, will be consumed during 2 phases) and FP supplementation (will be consumed during one phase only). During the final 2-d of each phase, participants will live in a hypobaric chamber under sea level or high altitude conditions.
Conditions: Gastrointestinal Injury, Acute Mountain Sickness.
Primary outcome: Difference in intestinal permeability.
Enrollment: 33 participants.
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 33 participants or records.
Read the paper
Related studies
- Climate Change Impacts on Marine Ecosystems
- Assisted Gene Flow to Facilitate Local Adaptation to Climate Change
- Climate Change Effects on Plant Disease: Genomes to Ecosystems
- Biodiversity and Climate Change: Integrating Evolutionary and Ecological Responses of Species and Communities
- A systematic review of climate change education: giving children and young people a ‘voice’ and a ‘hand’ in redressing climate change
- Global Monsoon Dynamics and Climate Change
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.