Testing 'mommy brain': no evidence of altered memory-related brain function across the transition to motherhood
Abstract
Abstract Pregnancy induces structural brain changes, but effects on task-based brain function remain unexamined. Here we investigated verbal memory-related brain function across this transition using a pre-conception longitudinal fMRI design in 110 women (first-time and second-time mothers, and nulliparous controls), and assessed memory and subjective complaints in an independent replication cohort (n=144). No significant group differences in encoding-related brain activity or objective memory performance were observed. Both maternal groups reported significant, persistent increases in subjective memory complaints, absent in controls and linked to change in depressive symptoms and perceived stress rather than pregnancy itself. These findings show no evidence of decline in memory-related brain function or performance, and suggest that psychological wellbeing, not pregnancy or parity, shapes both subjective complaints challenging the neurobiological basis of a 'mommy brain'.
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 144 participants or records.
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