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Glycine Supplementation Improves Cognitive Performance in Mexican Older Adults

ClinicalTrials.gov · COMPLETED, 2025

59 participants

Abstract

The purpose of this study was to evaluate the effects of daily glycine supplementation on metabolic health and cognitive performance in older adults. Over a period of six months, participants received 1,000 mg of glycine per day to determine if this amino acid could improve markers of insulin resistance, glucose metabolism, and cognitive functions such as memory and executive tasks.

The research aimed to identify whether this nutritional intervention provides a safe and effective strategy to support healthy aging, focusing on the link between metabolic balance and brain health in the elderly population.

Conditions: Older Adults With Cognitive Decline, Insulin Resistance Syndrome, Aging.

Primary outcome: Brain-Derived Neurotrophic Factor (BDNF) levels.

Enrollment: 59 participants.

How strong is the evidence?

Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 59 participants or records.

How the five levels of evidence work. The level is assigned automatically from the abstract and can be wrong, so check the paper.

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