Pioglitazone as an Adjunct to Cognitive-Behavioral Therapy for Cocaine Relapse Prevention
Abstract
The purpose of this study is to see how well pioglitazone, when used with cognitive behavioral therapy, works at helping people who have recently stopped using cocaine to continue to not use cocaine.
Conditions: Cocaine Use Disorder.
Primary outcome: Change in white matter integrity as assessed by change in fractional anisotropy value measured by diffusion tensor imaging; Change in white matter integrity as assessed by change in radial diffusivity value measured by diffusion tensor imaging; Change in working memory as assessed by the NIH Toolbox Cognition Battery List Sorting Task; Change in working memory as assessed by the NIH Toolbox Cognition Battery List Sorting Task; Change in working memory as assessed by the NIH Toolbox Cognition Battery List Sorting Task; Change in attention/impulsivity as assessed by the NIH Toolbox Cognition Battery Flanker Test; Change in attention/impulsivity as assessed by the NIH Toolbox Cognition Battery Flanker Test; Change in attention/impulsivity as assessed by the NIH Toolbox Cognition Battery Flanker Test; Change in cognitive function as assessed by the NIH Toolbox Cognition Battery Fluid Cognition Composite score; Change in cognitive function as assessed by the NIH Toolbox Cognition Battery Fluid Cognition Composite score; Change in cognitive function as assessed by the NIH Toolbox Cognition Battery Fluid Cognition Composite score; Number of participants who don't relapse as assessed by continuous cocaine-negative urine drug screens in…
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 61 participants or records.
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