Testing Whether Choline Normalizes Lipid Metabolism in APOE4 Carriers
Abstract
The purpose of this study is to test the safety, tolerability, and effects of choline in people with increased risk of Alzheimer's Disease (AD), also known as pre-symptomatic AD. Choline is a dietary supplement, but is being investigated to see if it has any effects on the progression to AD.
Conditions: Alzheimer Disease.
Primary outcome: Changes in the fatty acid desaturation index (FADI) in the CSF following choline supplementation; Changes in phosphatidylcholine (PC) in the CSF following choline supplementation.
Enrollment: 15 participants.
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 15 participants or records.
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