Association of Metformin Treatment with Risk for Death in Diabetic Patients with Concomitant Gastric Cancer
Abstract
Simple Summary During the 5-year follow-up within the study period, the cumulative incidence of all-cause death was notably lower in the metformin treatment group compared to the non-treatment group (27.5% vs. 32.8%). The analysis further revealed a significantly reduced hazard ratio (HR) for all-cause death in the metformin treatment group (HR: 0.80, 95% CI 0.78–0.82). This population-based cohort study provides evidence that long-term metformin treatment is associated with a decreased risk of mortality among individuals who have both diabetes and gastric cancer. Abstract Importance: Despite the existing guideline’s recommendation of metformin therapy as the initial approach for managing diabetes mellitus (DM), there remains a scarcity of comprehensive documentation regarding metformin’s impact on outcomes that are important for patients. Objectives: The objective of this study was to assess the potential impact of metformin treatment on the risk of death in individuals diagnosed with both gastric cancer and pre-existing diabetes mellitus (DM); Design, Setting, and Participants: The study made use of a dataset encompassing nationwide health insurance claims, allowing for a retrospective analysis of all patients with a history of gastric cancer diagnosis (classified under International Classification of Diseases 10th Revision code: C16.X) spanning from 1 January 2002 to 31 December 2012. The primary objective was to observe death within a 5-year follow-up period. The study…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 63,664 participants or records.
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