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Cognitive Stimulation and Training in People with Mild-to-Moderate Alzheimer's Disease: A Scoping Review

Martins R, Carvalho N, Loureiro R, Loureiro JB

Brain sciences, 2026

245 participants

Abstract

Background/objectives: Cognitive stimulation and cognitive training are used as non-pharmacological approaches to support people living with Alzheimer's disease, but Alzheimer-specific evidence is dispersed across heterogeneous intervention formats. This scoping review mapped structured cognitive stimulation and training interventions evaluated in people with mild-to-moderate Alzheimer's disease and summarized the cognitive, emotional, functional, and follow-up outcomes reported.

Methods: The review was conducted using the Joanna Briggs Institute methodology and reported according to PRISMA-ScR. PubMed, SciELO, PEDro, LILACS, and Google Scholar were searched on 24 February 2025 for studies published between January 2015 and 24 February 2025 in English, Portuguese, or Spanish. Intervention studies were eligible. Two reviewers independently screened records and charted data, with disagreements resolved by a third reviewer.

Results: Of 352 records identified, five studies involving 245 participants were included. Interventions comprised virtual-reality cognitive stimulation, conventional cognitive training, group reminiscence therapy, a multicomponent music-reminiscence-reality-orientation intervention, and computerized cognitive training. In the limited technology-assisted evidence, statistically significant changes were reported in global cognition or selected memory, language, attention, and executive outcomes. Conventional cognitive training showed signals of improvement in…

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