Understanding subset diversity in T cell memory
Abstract
Summary Considerable advances have been made in recent years in understanding the generation and function of memory T cells. In this review, we consider new developments in the field and focus on how emerging differences between memory cells with respect to their trafficking, metabolism, epigenetic regulation and longevity may fail to fit into small groups of “memory subsets”, but rather that the properties of individual memory cells fall on a continuum within each of these (and other) parameters. How that influences the way we assess the efficacy of vaccination and suitability (or not) of a memory population for protective immunity is also discussed.
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