Robustness of radiomics within photon-counting detector CT: impact of acquisition and reconstruction factors
Abstract
OBJECTIVES: To assess the impact of acquisition and reconstruction factors on the robustness of radiomics within photon-counting detector CT (PCD-CT).
METHODS: A phantom with twenty-eight texture materials was scanned with different acquisition and reconstruction factors including reposition, scan mode (standard vs high-pitch), tube voltage (120 kVp vs 140 kVp), slice thickness (1.0 mm vs 0.4 mm), radiation dose level (0.5 mGy, 1.0 mGy, 3.0 mGy, 5.0 mGy, vs 10.0 mGy), quantum iterative reconstruction level (0/4, 2/4, vs 4/4), and reconstruction kernel (Qr40, Qr44, vs Qr48). Thirteen sets of virtual monochromatic images at 70-keV were reconstructed. The regions of interest were drawn with rigid registrations. Ninety-three radiomics features were extracted from each material. The reproducibility of radiomics features was evaluated using the intraclass correlation coefficient (ICC) and concordance correlation coefficient (CCC). The variability of radiomics features was assessed by coefficient of variation (CV) and quartile coefficient of dispersion (QCD).
RESULTS: The percentage of features with ICC > 0.90 and CCC > 0.90 were high when repositioned (88.2% and 88.2%) and tube voltage was changed (87.1% and 87.1%), but none of the features with ICC > 0.90 and CCC > 0.90 when high-pitch scan and different slice thickness were used. The percentage of features with CV < 10% and QCD < 10% were high when repositioned (47.3% and 68.8%) and tube voltage was changed (64.2% and 71.0%),…
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