Acupuncture improves anxiety and depression in patients with polycystic ovary syndrome: a systematic evaluation and meta-analysis
Abstract
Background: Acupuncture is increasingly utilized to address anxiety and depression in polycystic ovary syndrome (PCOS), yet evidence for non-pharmacological interventions remains limited. This study aimed to rigorously evaluate the efficacy and safety of acupuncture in alleviating anxiety and depression among women with PCOS, while exploring its potential mechanisms.
Methods: Eight Chinese/English databases (CNKI, Web of Science, PubMed, Embase, etc.) were searched from inception to March 1, 2025. Two investigators independently screened studies, extracted data, and assessed quality via the Cochrane risk-of-bias tool. The meta-analyses were performed with RevMan 5.4. Additionally, data mining methods were used, including frequency statistics to analyze the frequency of acupuncture points and the meridians involved.
Results: Twelve RCTs (n = 2,127 patients; acupuncture = 1,059, control = 1,068) were included. Compared with the control, acupuncture significantly reduced anxiety scores [MD = -6.42, 95% CI (-8.91, -3.56); p p = 0.0002] versus controls. Acupuncture also improved testosterone [MD = -0.05, 95% CI (-0.11, 0.00); p = 0.05], BMI [MD = -0.70, 95% CI (-1.19, -0.21); p = 0.005], and the waist-hip ratio [MD = -0.06, 95% CI (-0.11, -0.01); p = 0.03], with no significant adverse effects [OR = 0.08, 95% CI (0.01, 0.81); p = 0.03]. The effects on insulin resistance were not significant [MD = -0.41, 95% CI (-1.18, 0.37); p = 0.31]. Data mining revealed that Foot Taiyin Spleen…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 2,127 participants or records.
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