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Review of current therapeutic approaches for polycystic ovary syndrome

Teodora Mitrovic, A. Bjelica, Djordje Petrovic, D. Stajic

Medicinski pregled, 2024

Abstract

Introduction. Polycystic ovary syndrome is a multifaceted endocrine disorder

affecting 5-15% of women of reproductive age. This review aims to explore

and synthesize current therapeutic strategies for managing polycystic ovary

syndrome, emphasizing lifestyle modifications, pharmacological treatments,

and emerging alternative therapies. A systematic literature search was

conducted, focusing on randomized controlled trials, metaanalyses, and

observational studies examining interventions that improve metabolic,

reproductive, and psychological outcomes in women with polycystic ovary

syndrome. Current Therapeutic Strategies. Lifestyle interventions, including

weight management and regular exercise, are fundamental in enhancing insulin

sensitivity and alleviating symptoms such as menstrual irregularities and

hirsutism. Pharmacological treatments, including hormonal contraceptives,

metformin, and anti-androgens, play a vital role in managing

hyperandrogenism and promoting fertility. Additionally, emerging therapies,

such as glucagon-like peptide-1 receptor agonists and herbal supplements,

show potential in addressing metabolic dysfunction. Nutritional

supplementation, particularly vitamin D, folic acid, and omega-3 fatty

acids, has demonstrated benefits in improving both metabolic and

reproductive outcomes. Complementary treatments, including acupuncture and

herbal medicine, also hold promise but require further validation through

robust clinical research. Conclusion. A…

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