Impaired Respiratory Function in Women With PCOS Compared With Matched Controls From a Population-Based Study
Abstract
CONTEXT: Increased prevalence of asthma has been reported from epidemiological studies in women with polycystic ovary syndrome (PCOS).
OBJECTIVE: To investigate respiratory function in women with PCOS compared with controls in a clinical setting.
DESIGN: An 8-year clinical follow-up study including self-reported asthma diagnoses and spirometry of women with PCOS randomized to metformin or placebo during pregnancy in the original studies (the Pilot and the PregMet-study), compared with matched controls from a population-based cohort study (The HUNT Study).
SETTING: Secondary and tertiary care centers.
PARTICIPANTS: A total of 145 women with PCOS (54% of original cohort) were matched 1:3 to controls, on gender, age, and smoking-status.
MAIN OUTCOMES AND MEASURES: Self-reported doctor-diagnosed asthma (DDA), percentage of predicted forced expiratory volume in the first second of expiration (FEV1 % predicted), percentage of predicted forced vital capacity (FVC % predicted).
RESULTS: Women with PCOS reported more DDA compared with controls (19% vs 9%; P < 0.01). Spirometry indicated a combined obstructive (FEV1 % predicted, 93.7 vs 102.0; P < 0.01) and restrictive (FVC % predicted, 94.5 vs 103.7; P < 0.01) respiratory impairment in PCOS compared with controls. Metformin in pregnancy did not affect respiratory function at follow-up.
CONCLUSION: Women with PCOS reported higher prevalence of DDA compared with controls matched for age and smoking status. In addition, respiratory…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 145 participants or records.
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