The effect of metformin treatment to ovarian response in cases with PCOS.
Abstract
OBJECTIVE: To examine the effect of metformin therapy on ovarian response in clomiphene-resistant PCOS patients.
DESIGN: Randomized prospective study.
SETTING: Zeynep Kamil Hospital IVF Center.
PATIENTS: Thirty-two female PCOS patients with clomiphene citrate resistance.
INTERVENTIONS: Test group A received 2x850 mg/day metformin therapy for 8 weeks, followed by gonadotropin induction. Only gonadotropin induction was applied to Control group B.
MAIN OUTCOME MEASURES: Total gonadotropin dosage, duration of gonadotropin therapy, estradiol level on HCG-day, number of follicles with >or=16 mm diameter, number of cases with hyperstimulation development, number of cancelled cycles, endometrial thickness on HCG-day, pregnancy outcome, multiple pregnancy rate.
RESULTS: The total gonadotropin doses given to metformin-study group was significantly lower than the control group. In addition, duration of therapy, HCG level, plasma estradiol level on HCG-day in the study group was significantly lower than in the control group.
CONCLUSIONS: Metformin therapy has led to a higher pregnancy outcome, as well as to a decrease in hyperstimulation risk, cycle cancellations, and multiple pregnancy rates with a lower gonadotropin dosage.
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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