Preconception dietary patterns and time-to-conception in the high-income multi-country NiPPeR study
Abstract
BACKGROUND: Dietary patterns rich in plant-based foods, fish, and healthier fats are reportedly beneficial for fertility, but forming generalizable recommendations has been hindered by the lack of studies examining dietary patterns and time-to-conception (TTC) in cohorts with different ethnicities across geographical regions. To study the association of preconception dietary patterns with TTC in the multi-country NiPPeR trial. METHODS: This study is a secondary analysis of data collected in the NiPPeR randomized controlled trial. Women planning to conceive, without known fertility impairment, were recruited from the community in the UK, Singapore, and New Zealand (NZ). Dietary intake was assessed at preconception prior randomization, and across-site (“pooled”) data-driven dietary patterns were derived (n = 1406). TTC, derived as the number of days between recruitment and the estimated date of achieving a clinical pregnancy, and the chance of achieving a clinical pregnancy within a year, expressed as hazard ratios (HR), were analyzed using Cox proportional hazards models adjusted for preconception body mass index, age and gravidity. RESULTS: Two pooled dietary patterns were identified: “Vegetables, Fruits and Nuts” (VFN), and “Fried potatoes, Processed meat and Sweetened beverages” (FPS). Compared with the lowest quartile of VFN score, those in the highest quartile took a shorter time to conceive [Days till 20% conceived (95% CI): 73.0 (60.6, 91.5) vs 166.5 (120.0, 229.5)],…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 1,406 participants or records.
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