Myo-Inositol versus Metformin in Women with Polycystic Ovarian Syndrome Undergoing Induction of Ovulation - A Randomized Controlled Trial
Abstract
Background: Polycystic ovary syndrome (PCOS) is a reproductive endocrine disorder that affects a significant number of young women worldwide. Objective: to assess the effectiveness of induction of ovulation with Aromatase Inhibitors (letrozole) in women with PCOS via myoinositol versus metformin. Materials & Methods: In this randomized clinical trial, 66 women who were undergoing ovulation induction and were separated into two groups, each consisting of 33 infertile women who met the criteria of Rotterdam for PCOS. The study was carried out at Menoufia university Hospital and outpatient clinic from May 2023 to july 2024. Results: Demographic characteristics, cumulative pregnancy, and ovulation rate did not exhibit any significant variances among the two groups. Fasting insulin during the follow-up was considerably lower in comparison with the baseline level in each group. The myoinositol group exhibited a significant decrease in comparison to the metformin group. Conclusion: we advise some PCOS patients that there is no significant difference between metformin and myoi-nositol regarding ovulation and pregnancy rates. It should also highlight that myoinositol is not inferior to metformin.
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 66 participants or records.
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