Effects of Low Molecular Weight Heparin on Early Pregnancy Loss in Women With Polycystic Ovary Syndrome
Abstract
Objective: To evaluate the early pregnancy loss (EPL) rates in women with and without low molecular weight heparin (LMWH) treatment during early pregnancy.
Methods: A retrospective, non-randomized study was conducted at Guangzhou Women and Children's Medical Center between June 2019 and March 2022, involving women diagnosed with polycystic ovary syndrome (PCOS). All participants conceived following standard preconception care and voluntarily chose either the control group or the LMWH intervention group during the first month of pregnancy. The intervention was administered throughout the entire first trimester. Early and final pregnancy outcomes were recorded, with a particular focus on EPL rates. In addition, venous blood samples and clinical data were collected to compare hormonal profiles, blood lipid levels, and anthropometric parameters between the two groups. Statistical analyses included the two-tailed unpaired Student's t-test, Mann-Whitney U test, Chi-square test, and Kaplan-Meier survival analysis. A value of P < 0.050 was considered statistically significant.
Results: Thirty-eight women in the LMWH group and 102 women in the control group were included. The EPL rates in the LMWH and control groups were 5.3% (2/38) and 26.5% (27/102), respectively (χ 2 = 7.582, P = 0.006, odds ratio (OR) = 0.154, 95% confidence interval (CI): 0.035-0.685). The age (P = 0.005), PCOS subtype (P = 0.012), and levels of total cholesterol (P = 0.003), and high-density lipoprotein (P =…
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