Free testosterone independently predicts metabolic syndrome severity in U.S. adolescent girls aged 12-19 years
Abstract
Context: Hyperandrogenemia is associated with increased risks for metabolic syndrome in asymptomatic women and women with polycystic ovary syndrome. The relationship between hyperandrogenemia and metabolic syndrome in adolescent girls remains poorly defined.
Objective: The aim of this study was to assess whether free testosterone concentrations predict metabolic syndrome severity (MSS) in adolescent girls.
Design/setting: Using data from the U.S. National Health and Nutrition Examination Survey (2013-2016), we performed weighted regression analysis to evaluate whether free testosterone predicts MSS z-score after adjusting for body fat percentage, chronological age, and gynecological age. Similar analyses were performed using either total testosterone or sex hormone-binding globulin (SHBG) as the primary predictor variable.
Participants: 287 girls aged 12-19 years.
Main outcome measure: MSS z-score.
Results: In simple regression analyses, free testosterone and percent body fat predicted MSS z-score (R 2 = 0.11 and 0.35, respectively; P R 2 = 0.41), higher free testosterone and percent body fat were independently associated with higher MSS z-score (P = .0081 and P = .0104) in a multivariable regression model, total testosterone was not (P = .77).
Conclusion: Higher free testosterone predicts greater MSS in a nationally representative sample of adolescent girls aged 12-19 years. This relationship at least partly reflects the relationship between MSS z-score and SHBG.
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