P-415 Prevalence of Polycystic Ovary Syndrome Prevalence in Patients with Recurrent Early Pregnancy Loss: a Canadian Population Study
Abstract
This study aims to determine the prevalence of Polycystic Ovary Syndrome (PCOS) in patients with Recurrent Early Pregnancy Loss (REPL) in a Canadian population.
Among the 1000 women with REPL, 245 (24.5%) met the diagnostic criteria for PCOS.
REPL presents a significant challenge, impacting approximately 2-5% of couples attempting to conceive. It is defined as the loss of two or more pregnancies before 12 weeks of gestation. Over the years, research has explored the relationship between REPL and PCOS, a complex endocrine disorder prevalent among women of reproductive age. Numerous studies have attempted to understand this relationship.
This retrospective cohort study includes patients treated in a culturally diverse, private fertility practice in Toronto, Ontario, Canada. A thorough review of 1000 patient charts meeting the REPL criteria from 2008 to the present was conducted.
PCOS diagnosis was determined based on the Rotterdam criteria, which requires two of the following: polycystic ovarian morphology or ovarian volume ≥10 cc on ultrasound, oligo- or anovulation, and clinical or biochemical hyperandrogenism. Demographic and clinical characteristics were analyzed as potential confounding factors. In addition, in a subset of the population diagnosed with REPL and PCOS, metformin was prescribed, and reproductive outcomes were followed.
Among the 1000 women studied, 245 (24.5%) met the diagnostic criteria for PCOS. Those diagnosed with PCOS were significantly younger (p <…
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