Successful Pregnancy in a Patient with Polycystic Ovary Syndrome Following Lifestyle Modification and Pharmacological Intervention: A Case Report
Abstract
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age, often associated with obesity and fertility problems. This case report documents the management of a 32-year-old female patient diagnosed with Polycystic Ovary Syndrome (PCOS), who sought to conceive. Despite having normal hormonal levels, the patient exhibited insulin resistance, a common feature in PCOS. Intervention strategies included pharmacotherapy (metformin, spironolactone, and phentermine) and lifestyle modifications leading to significant weight loss (10.5% of total body weight). The treatments led to an improvement in the patient's metabolic profile, menstrual regularity, and reduction in hyperandrogenic symptoms. By December 2021, the patient had maintained her weight loss and improved metabolic parameters. She successfully conceived in January 2022 and delivered a healthy baby at term in August 2022. This case underscores the importance of weight management and metabolic control in improving fertility outcomes in patients with PCOS.
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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