Role of Choline and Inositol Treatment for Patients with Polycystic Ovarian Syndrome: A Clinical Study
Abstract
Background: The most frequent cause of infertility, hyperandrogenism, and ovulatory problems is polycystic ovarian syndrome (PCOS). One of the most common diseases in the world. Management of insulin resistance, which is based on dietary habits, exercise, and other molecules like inositol, is crucial in the treatment of PCOS. In polycystic ovary syndrome, inositol is useful in restoring ovarian function and enhancing oocyte and embryo quality. Objective: Comparison of the effectiveness of choline and inositol vs metformin and non-insulin sensitizers in polycystic syndrome patients. Materials and Methods: A case-control research carried out in the Iraqi city of Nasiriyah from March 2021 to December 2021. There were 150 PCOS patients. There were three categories of patients: Metformin with clomiphene citrate in Group 1, choline and inositol with clomiphene citrate in group 2 and clomiphene citrate alone in group 3. Six months of drug therapy were provided to all groups, followed by evaluation. Results: During follow-up, mean BMI decreased significantly by an average of 1.9 ± 4.2 kg/m 2 (p = 0.001). Regarding cycling, regular cycling was significantly higher in the metformin group (p = 0.001). The mean change in follicle size was 2.9 mm, which decreased significantly after treatment initiation (p=0.001). Both LH and FSH increased significantly after treatment initiation (p=0.0001). Subsequent LH distribution was not significantly different between the drug groups (p=0.5),…
How strong is the evidence?
Evidence Hub reads this as a case-control, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 150 participants or records.
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