Protective Effect of Hydroethanolic Extract of Lippia citrodora L. Leaf and Vitamin D3 on Estradiol Valerate-Induced Polycystic Ovary Syndrome in Mice
Abstract
Methods: This experimental study was performed on 48 female suri rats with a weight range of 25-35g. The subjects were divided into 8 groups (n=6 each), namely control (food + water), case (estradiol valerate, subcutaneously), sham (sesame oil, 0.25 ml, subcutaneously), positive control (metformin + water), intervention 1 (estradiol valerate + low-dose Lippia citrodora L. extract, intraperitoneally), intervention 2 (estradiol valerate + LCE high dose, intraperitoneally), intervention 3 (estradiol valerate + vitamin D3, intraperitoneally), and intervention 4 (estradiol valerate + Lippia citrodora L. extract + vitamin D3). The whole process of performing the experiments took 55 days. To conduct the study, blood and ovary tissue samples were obtained from the subjects. The collected data were analyzed in SPSS software (version 24) using the one-way ANOVA method.
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