Frequency of Impaired Oral Glucose Tolerance Test Results in Women with Polycystic Ovary Syndrome
Abstract
OBJECTIVE
To determine the frequency of impaired Oral Glucose Tolerance Test (OGTT) results in women with Polycystic Ovary Syndrome (PCOS) attending a tertiary-care gynaecology outpatient clinic.
STUDY DESIGN
A cross-sectional observational study. Place and Duration of the Study: Department of Obstetrics and Gynaecology, MTI-Hayatabad Medical Complex, Peshawar, Pakistan, from June to December 2024.
METHODOLOGY
Consecutive women aged 18-45 years who met the Rotterdam criteria for PCOS were enrolled. Exclusion criteria included known diabetes mellitus, pregnancy, and use of medications affecting glucose metabolism, except for metformin. A standard 75-g OGTT was performed after an overnight fast (≥8 hours). Fasting and 2-hour plasma glucose levels were categorised using American Diabetes Association definitions. Demographic, clinical, and lifestyle variables were recorded. Associations between OGTT categories and categorical variables were tested using the chi-square test (α = 0.05).
RESULTS
A total of 360 participants were analysed (mean age: 30.44 ± 6.14 years; mean BMI: 28.30 ± 5.27 kg/m2). Normal glucose tolerance occurred in 50.0% (n = 180) participants, impaired glucose tolerance in 37.5% (n = 135), and diabetes in 12.5% (n = 45). No statistically significant associations were observed between OGTT category and menstrual regularity, family history of diabetes, hypertension, dyslipidaemia, physical activity, dietary pattern, insulin resistance, medication use, or smoking…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 360 participants or records.
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