Free Testosterone, Dihydrotestosterone, and Adiponectin in the Evaluation of Vitamin D Supplementation for Polycystic Ovarian Syndrome: A Metformin Comparative Study
Abstract
Background: Among women of the reproductive age, the most prevalent endocrine disease with (15-44) percentile is the polycystic ovarian syndrome (PCOS). Last decades, many studies indicated that vitamin D deficiency in women with PCOS may aggravate hyperandrogenism and insulin resistance.
Objectives This study was designed to investigate the role of some biochemical markers and hormonal status in evaluation the efficacy of vitamin D supplementation in treatment of polycystic ovary syndrome.
Subjects and Methods: This cross-sectional study was carried out at Department of Biochemistry, College of Medicine, University of Baghdad. It included: group I: Twenty-five women with PCOS who were treated with metformin and followed for 8 weeks, and group II: Twenty-five women with PCOS who were treated with vitamin D3 and followed for 8 weeks. Serum investigations included measurements of HOMA-IR, 25 hydroxyvitamin D3, adiponectin, androgen indices by ELISA technique
Results: The mean (±SD) values of HOMA-IR, free testosterone, dihydrotestosterone, and adiponectin levels were significantly improved after treatment in both groups of metformin and vitamin D supplement compared with before their treatment (p 0.05). PCOS women treated with vitamin D showed significant negative correlation between SHBG and BMI (r= -0.976, p <0.001)
Conclusions: Measurements of serum free testosterone, dihydrotestosterone and adiponectin are good indicators for efficacy of vitamin D supplement in improvement…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
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