Frequency of efficacy of metformin in pregnant female with pcos with regards to development of gestational diabetes mellitus
Abstract
Background
Polycystic ovary syndrome (PCOS) is a significant gynecological problem manifested by raised androgen level, menstrual irregularities, and/or one or both ovaries having small cysts. Metformin has shown to have promising effects on PCOS and its several metabolic aspects. The metformin used as therapy in these patients during pregnancy have beneficial effects regarding development of GDM.
Objective
To determine the frequency of efficacy of metformin in pregnant female with PCOS with regards to development of Gestational Diabetes Mellitus
Material and methods
Setting: The study was conducted in Jinnah Hospital, Lahore
Study design: Descriptive cross sectional study
Study duration: Six months from: 04-06-2018 to 04-12-2018
Data collection procedure: A total of 220 cases fulfilled the inclusion/exclusion criteria were enrolled. All cases were followed up till delivery for presence/absence of GDM. The frequency of efficacy in patients with PCOS was noted; all this information was recorded on a pre-designed proforma. Data was entered and analyzed in SPSS version for 16.0.
Results
The mean age of patients was 30.50±6.08years. About 36 (16.4%) females had parity 0, 51 (23.2%) had parity 1, 59 (26.8%) had parity 2, 42 (19.1%) had parity 3 and 32 (14.6%) had parity 4. The mean BMI of patients was 26.81±4.55kg/m2. Efficacy of metformin was achieved in 190 (86.4%) cases while in 30 (13.6%) cases efficacy could not be achieved.
Conclusion
It has been inferenced that metformin…
Read the paper
Related studies
- Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis
- Identification of key genes associated with polycystic ovary syndrome (PCOS) and ovarian cancer using an integrated bioinformatics analysis
- Identification of key pathways and genes in polycystic ovary syndrome via integrated bioinformatics analysis and prediction of small therapeutic molecules
- Regulation of Androgen Receptor Expression Alters AMPK Phosphorylation in the Endometrium: In Vivo and In Vitro Studies in Women with Polycystic Ovary Syndrome
- Effect of oral administration of low-dose follicle stimulating hormone on hyperandrogenized mice as a model of polycystic ovary syndrome
- Systems pharmacology to investigate the interaction of berberine and other drugs in treating polycystic ovary syndrome
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.