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Analysis of the relationship between medication compliance and quality of life of pcos patients in west java

S. A. R. Lestari, A. K. Dewi, Zulkaida, Roudotul Farikhah, Imam Abdul Aziz

Medical Sains : Jurnal Ilmiah Kefarmasian, 2026

Abstract

Polycystic Ovary Syndrome (PCOS) is the most common cause of infertility and affects the quality of life through lifelong symptoms. Specifically, the impact on women's quality of life is related to difficulty in losing weight, irregular menstrual cycles, infertility, and hirsutism. Consequently, given these challenges, medication compliance can influence therapy success, as patients with PCOS use several pharmacological interventions to improve their quality of life. This study aimed to analyze the relationship between medication adherence and quality of life in PCOS patients in West Java. Using a cross-sectional design and purposive sampling, we assessed medication adherence using the Medication Adherence Report Scale-5 (MARS-5) and quality of life using the EuroQol EQ-5D-5L questionnaire. Of the 53 respondents, 27 showed low medication adherence and 26 showed high adherence. Most used metformin and vitamin D. The overall EQ-5D-5L index was good (0.848 ± 0.125). Respondents with low adherence had a slightly lower score (0.833 ± 0.127, VAS = 75.66 ± 15.99) than those with high adherence (0.863 ± 0.123, VAS = 80.13 ± 14.41). Spearman’s correlation showed no significant relationship between medication adherence and utility score or VAS (p>0.05). While medication adherence did not significantly affect quality of life, several factors, such as dietary and physical activity status, may have influenced this result. Furthermore, each patient may have diverse needs and treatment…

How strong is the evidence?

Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.

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