Role of Metformin in Preeclampsia: A Systematic Review
Abstract
Background: Preeclampsia is a leading cause of maternal and newborn morbidity and mortality. Metformin prevents preeclampsia by improving cardiovascular function and reducing gestational weight gain.
Aim: The aim of systematic review was to summarize the role of metformin in preeclampsia and report on outcomes of role of metformin in preeclampsia.
Objective: To assess the maternal and perinatal outcomes among women with preclamsia with or without metformin supplementation in addition to usual care.
Method: We searched for publications indexed in PubMed, Web of Science, Psyc INFO, and CINAHL databases using a combination of terms such as "metformin" AND "preeclampsia" OR "hypertension" AND "gestation."
Results: Four empirical studies were identified as relevant to our study. We discovered that the incidence of severe preeclampsia was significantly lower in those who received metformin than in those who did not (12.1% vs. 20.7%, aOR 0.38, 95% CI 0.18-0.81). Metformin treatment significantly reduced the incidence of preeclampsia (P = 0.04) and intrauterine growth restriction (P = 0.035) compared to the control group. One week after taking metformin, maternal sEng and sFLT-1 levels were considerably reduced.
Conclusions: Our findings reveal that Metformin significantly reduced the frequency of superimposed preeclampsia and associated factors in a pregnant woman with chronic hypertension. When compared to other drugs, metformin is more likely to avoid pregnancy-related…
How strong is the evidence?
Evidence Hub reads this as a systematic review, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- Metformin as an adjuvant in breast cancer treatment
- Metformin Lysosomal Targeting: A Novel Aspect to Be Investigated for Metformin Repurposing in Neurodegenerative Diseases?
- Aberrant HSF1 signaling activation underlies metformin amelioration of myocardial infarction in mice
- Metformin induces ZFP36 by mTORC1 inhibition in cervical cancer-derived cell lines
- Protein Interaction Network for Identifying Vascular Response of Metformin (Oral Antidiabetic)
- Preventing Long COVID With Metformin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.