The impact of vitamin D supplementation on anti-Müllerian hormone levels: a systematic review and meta-analysis
Abstract
Background: The possible anti-Mullerian hormone (AMH)-reduction impact of vitamin D supplementation has been assessed in a number of interventional investigations. The outcomes are still incongruous, however. This research sought to thoroughly examine the effects of vitamin D supplementation on AMH in order to have a better understanding of them.
Methods: Using standard keywords, the Scopus, PubMed/Medline, Web of Science, Cochrane, and Embase databases were searched to find all controlled trials examining the levels of AMH after vitamin D treatment. For the best result estimate, random-effects model analysis produced 95% confidence intervals and a pooled weighted mean difference.
Results: This article includes sixteen research with a total of 484 participants. Vitamin D supplementation did not significantly affect AMH levels in single-arm (pooled WMD of -0.22 ng/ml; 95% CI -0.68 to 0.23; P = 0.333) or randomized clinical trial (pooled WMD of -0.07 ng/ml; 95% CI -1.01 to 0.87; P = 0.887) studies, according to pooled results from the random-effects model. Vitamin D during the intervention < 8 weeks and in individuals with low baseline levels of vitamin D serum induces a higher drop in AMH levels, according to the findings of subgroup analysis.
Conclusions: Despite the inconclusive and conflicting evidence on the relationship between vitamin D supplementation and AMH levels in women, it is evident that vitamin D may play a role in mitigating the negative impact of AMH on…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 484 participants or records.
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