Triplet pregnancy after metformin in a woman with polycystic ovary syndrome
Abstract
OBJECTIVE: To report a case of triplet pregnancy after metformin treatment only, in a woman with polycystic ovary syndrome (PCOS) and a family history of twin pregnancies.
DESIGN: Case report and literature review.
SETTING: Gynecologic endocrinology clinic, tertiary federal hospital.
PATIENT(S): A white, lean, 34-year-old woman, treated for PCOS since age 28, who had tried to conceive spontaneously for 6 months, with no evidence of ovulation.
INTERVENTION(S): Metformin, 850 mg, for 1.5 months.
MAIN OUTCOME MEASURE(S): Pregnancy (triplet).
RESULT(S): Pregnancy developed up to premature labor at 31 weeks. The patient delivered two boys and one girl, in need of neonatal intensive care for 33 to 44 days.
CONCLUSION(S): Despite the paucity of literature data, we believe that metformin, when associated with predisposing therapies or conditions, may facilitate high-order pregnancies.
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Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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