Therapeutic response to metformin in an underweight patient with polycystic ovarian syndrome
Abstract
OBJECTIVE: To report a case where insulin sensitization restored menses in an underweight woman with polycystic ovarian syndrome (PCOS).
DESIGN: Case report.
SETTING: Tertiary care center.
PATIENT(S): A 19-year-old woman with a body mass index of 16.9 kg/m(2), severe hirsutism, and oligomenorrhea.
INTERVENTION(S): Insulin sensitization with metformin.
MAIN OUTCOME MEASURE(S): Impact of metformin therapy on menstrual cycle and serum T and fasting insulin levels.
RESULT(S): Metformin, without weight loss or increased physical activity, resulted in restoration of menstrual cycle, reduction in serum T, and improvement in insulin resistance (IR).
CONCLUSION(S): This case highlights the contribution of PCOS-related IR, distinct from visceral adiposity, and demonstrates the effectiveness of pharmacological insulin-sensitization independent of weight loss or lifestyle adjustments.
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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