Exposure to High-Dose Liraglutide in a Pregnant Woman With Obesity
Abstract
Background: Animal studies indicate that liraglutide is not recommended for managing gestational diabetes mellitus and obesity during pregnancy due to potential developmental toxicity. We report a case of liraglutide exposure during the first trimester in a woman with obesity taking the maximum dose (3 mg subcutaneously daily), along with a neurodevelopmental assessment of the child conducted 14 months postpartum. Additionally, this report includes a literature review on the teratogenic effects of anti-obesity medications.
Case: A 29-year-old woman, gravida 9 para 6, with obesity and no history of chronic diseases was admitted at 7 weeks of gestation after taking liraglutide 3 mg/d subcutaneously for weight loss for 8 months. Liraglutide was immediately discontinued, and routine antenatal management was initiated. The patient underwent cesarean delivery at 37 weeks of gestation; the neonate had low birth weight but was otherwise healthy. Follow-up during 14 months postpartum indicated appropriate childhood weight gain and normal neurodevelopmental assessment for age.
Conclusion: This case report demonstrates a normal pregnancy outcome after exposure to a high dose of liraglutide during the first 7 weeks of pregnancy, apart from a low birth weight. These findings enhance the limited understanding of liraglutide exposure during pregnancy. More studies are required to establish a causal relationship between neonatal weight and liraglutide exposure. Longitudinal follow-up of…
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Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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