MON-150 Restoration of Fertility in Polycystic Ovarian Syndrome with Glucagon-Like Peptide-1 Therapy
Abstract
Abstract Disclosure: D. Fraser: None. B. Lam: None. M.M. Kristan: None. Introduction: Existing literature has demonstrated the link between improved fertility and metformin in women who are overweight with a history of PCOS [1]. A recent study reported that treatment of overweight/obese women with PCOS with diabetes using Glucagon-like peptide-1 receptor agonist (GLP-1 RA) monotherapy has led to weight loss and testosterone reduction [2]. A meta-analysis has shown that GLP-1 RAs improve natural pregnancy rate and insulin sensitivity in women with PCOS [3]. This case report will add to the existing literature hypothesizing increased fertility in women with PCOS due to GLP-1 RA improvement of insulin resistance. Clinical Case A mid-20s woman with history of PCOS, obesity, and type 2 diabetes, presented to the clinic for pre-conception weight loss and blood sugar management. Several years ago, she had successfully conceived her first child on metformin, but had begun to experience gastrointestinal side effects limiting her current use. She had been amenorrheic for 2 years and was given a weight loss/BMI goal prior to being eligible for IVF. Although she was interested in weight loss surgery, her diabetes remained uncontrolled with a hemoglobin A1c of 11.0. The patient was started initially on semaglutide in conjunction with her existing metformin and empagliflozin combination tablet, and eventually transitioned to tirzepatide given insurance changes. The patient had a dramatic…
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