L-Selectin and Adiponectin as Novel Biochemical-Immune Markers for the Response of Infertile Polycystic Ovary Syndrome Patients to Metformin Treatment
Abstract
Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting women throughout their lifespan. The prevalence of PCOS varies depending on the population studied, but it is estimated to affect between 10% and 13% or ∼140 million women globally. PCOS in adults is diagnosed according to the International Evidence-based Guideline Criteria based on two of either ovulatory dysfunction, clinical or biochemical hyperandrogenism, and/or polycystic ovary morphology (PCOM) on ultrasound or elevated anti-Müllerian hormone levels. Infertility is a serious global health problem affecting an estimated 50 to 70 million couples worldwide. Infertility is a condition in which pregnancy does not occur even after regular unprotected sex for more than one yearو for women under 35 years of age, a couple's failure to conceive after 12 months of regular sexual activity without using contraception, and after 6 months for women 35 years of age or older. Infertility results in disability expressed through impaired function, social exclusion, and psychological trauma; thus, it is ranked by the World Health Organization as the fifth highest serious disability worldwide. Population of the study: This study included samples of 90 women of reproductive age (20-40 years). They were distributed into three groups. The first: included 30 patients undergoing treatment for infertility due to PCOS, the second group included 30 patients who were diagnosed with PCOS through the simultaneous…
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