Effect of metformin therapy in patients with polycystic ovary syndrome (pcos) : a review
Abstract
Polycystic ovary syndrome (PCOS) is a common and heterogeneous disorder of women of reproductive age,characterized by hyperandrogenism and chronic anovulation. Metformin may lower the androgen level in follicularfluid, affecting local levels of IGFs, and may produce improved ovarian stimulation. Metforminis used in PCOS cases in order to decrease plasmaLH, hyperinsulinemia, and ovarian androgen levels.Metformin increases the ovulatory rate, cervical scores and pregnancy rate .This review article focuses on the effect of metformine administration in Polycystic Ovary Syndrome (PCOS)patients.
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