Between promise and peril: role of suzetrigine as a non-opioid analgesic
Abstract
In the current landscape of the opioid crisis, which was responsible for over 100,000 overdose deaths in the United States in 2022 alone, interest in the development of non-opioid analgesics has been considerable.1 Yet progress in developing novel analgesic drug treatments has been slow and as such, opioids continue to be used for many indications including the treatment of acute pain. This practice is problematic because use of opioids to treat acute pain, including for postoperative analgesia, is a known precursor for persistent opioid use.2 3 The most recent pain medication approved by the US Food and Drug Administration (FDA) was celecoxib in 1998.4 Although initially greeted with enthusiasm for its purported gastrointestinal safety relative to its non-steroidal anti-inflammatory drug (NSAID) counterparts, it received an FDA black box warning shortly thereafter as postmarketing data revealed evidence of serious and sometimes fatal cardiovascular and gastrointestinal risks. This denouement has long served as a cautionary tale for analgesic drug development.
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