Effects of Metformin on Inflammation Factors in Patients with Polycystic Ovary Syndrome
Abstract
Objective:To study the effects of metformin on inflammation factors and blood lipids in patients of polycystic ovary syndrome(PCOS).Method:Forty-three women with PCOS were divided into two groups depend on BMI,and were treated with metformin for three months.Chronic inflammation factors and blood lipids were measured in all patients before and after treatment.Result:After three months of treatment,serum levels of low density lipoprotein cholesterol(LDL-C),C-reactive protein(CRP,P0.01),tumour necrosis factor-alpha(TNF-a),interleukin-6(IL-6) decreased significantly,well high density lipoprotein cholesterol(HDL-C) was increased significantly(P0.05).In obese PCOS,The serum levels of C-reactive protein,tumour necrosis factor-alpha,interleukin-6 decreased more significantly than that in lean PCOS(P0.01).Conclusion:Metformin may effectively improve the lipids metabolism,decrease the levels of serum chronic inflammation factors and metabolism syndrome.
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